Super-Enhancer Transcription Converges on AID
نویسندگان
چکیده
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.
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ورودعنوان ژورنال:
- Cell
دوره 159 شماره
صفحات -
تاریخ انتشار 2014